Description

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ApoptosisInducingsiRNA(5nmol)

• siRNAtransfectioncontrol
• Kitincludes5nmolofready-to-usechemicallysynthesizedsiRNA
• siRNAinduceapoptosiswhentransfectedinvitro
• Validatedforuseinhumancelllines
• TransfectioncontrolforchemicaltransfectionandsiRNAelectroporationapplications
• DevelopedandmanufacturedbyAltogenBiosystems

siRNATransfection:

GenesilencingbyRNAInterference(RNAi)isapowerfulresearchtoolforstudyinggenefunctioninmammaliancells.RNAiisaBIOLOGicalphenomenonbywhichdoublestrandedRNA(dsRNA)specificallyreducesgeneexpressionofitscorrespondinggene.PotentinhibitionofspecificgeneexpressionisexperimentallyachievedbythetransfectionofsmallinterferingRNA(siRNA),whichbindsRISCcomplexandcausedegradationoftargetcomplementarymRNAmoleculesinthecell.Therefore,successful,potentRNAiexperimentationisdependentuponthehighlyefficientdeliveryofthesiRNAintocellsbytransfectionofstableandfunctionalsiRNAmolecules.MostDNAtransfectionreagentsareincompatIBLewithsiRNA,sensitivetoserum,orarecapableofinducingcytotoxicity,whichnegativelyaffectsgeneexpressionstudies.TransfectionReagentshavebeendevelopedandoptimizedspecificallyforusewithsiRNAtransfectionandallowtransfectioninthepresenceofserumwithoutloweringtransfectionefficiencyorreducingcellviABIlity.Ready-to-runtransfectionprotocolseliminatetheneedforextensivesiRNAoptimizationexperiments.AltogenBiosystemskitsarealsocompatiblefortransfectionofmicroRNA(miRNA)molecules.

AltogenBiosystemssiRNAarticlecitationreferences:

• CellDeathDiffer.2016.23(5):787-800.UnexpectedrequirementforabindingpartnerofthesyntaxinfamilyinphagocytosisbymurinetesticularSertolicells.Dongetal[PDF]

AltogenBiosystems:

AltogenBiosystemsisalifesciencescompanydedicatedtothedevelopment,marketingandmanufactureofcelltypespecifictransfectionreagents.EfficientdeliveryofDNA,RNA,siRNA,andmicroRNAenabledbyadvancedformulationofreagentsandpeculiardesignofprotocols.AltogenBiosystemsoffersacompletetransfectionsystemforabroadrangeofcelllines.Allreagentsarefunctionallytestedtobehighlyreproducible,serumcompatible,inducelowtoxicity,andcanbeusedforco-transfectionexperiments,andhighthroughputapplications.

AltogenResearchServices:

AltogenLabsprovidesGLP-compliantcontractresearchstudiesforpre-clinicalresearch,INDapplications,anddrugdevelopment.BiologyCROservices include:Xenograftmodels(30+),developmentofstablecelllines,ELISAassaydevelopment,cell-basedandtissuetargetedRNAistudies,safetypharm/toxassays,andotherstudies(visitAltogenLabs.com).

VolumeOptions:

• 5nmol(Catalog#4062)

Altogen Biosystems是一家开发和制造用于生命科学研究，药物发现和开发的转染试剂盒的生物技术公司。转染试剂盒针对特定癌细胞系和原代细胞培养进行了优化，可将生物分子有效递送到靶组织中。通过先进的试剂配方和优化的转染方案实现体外（癌细胞系）和体内（动物组织靶向试剂、癌细胞系）递送货物分子，包括质粒DNA，各种类型的RNA（mRNA，siRNA，shRNA，microRNA），蛋白质和小分子研究。

苏州蚂蚁淘代理Altogen Biosystems在中国的业务。Altogen Biosystems北京代理，Altogen Biosystems华东代理，Altogen Biosystems华北代理，Altogen Biosystems全国代理，Altogen Biosystems华南代理。