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LIPID-basedInVivoTransfectionKitforRodents(Mouse,Rat)
Figure1.Systemicadministration(i.v.)ofLipid-basedInVivoreagentconjugatedwithsiRNAtargetingLaminA/CmRNAornon-silencingcontrolsiRNAfollowingtherecommendedprotocol.TissueswerecollectedandRNAisolated48hoursafterfirstinjection.SampleswereanalyzedbyqRT-PCRforLaminA/Cgeneexpressionlevels.RibosomalRNAlevelswereusedtonormalizetheLaminA/Cdata.Dataaremeans±SD(n=6).
Figure2.Intratumoraladministration(i.t.)ofLipid-basedInVivoreagentconjugatedwithsiRNAtargetingLaminA/CmRNAornon-silencingcontrolsiRNAfollowingtherecommendedprotocol.TissueswerecollectedandRNAisolated48hoursafterfirstinjection.SampleswereanalyzedbyqRT-PCRforLaminA/Cgeneexpressionlevels.RibosomalRNAlevelswereusedtonormalizetheLaminA/Cdata.Dataaremeans±SD(n=6).
POLYMER-basedInVivoTransfectionKitforRodents(Mouse,Rat)
Figure3.Systemicadministration(i.v.)ofPolymer-basedInVivoreagentconjugatedwithsiRNAtargetingLaminA/CmRNAornon-silencingcontrolsiRNAfollowingtherecommendedprotocol.TissueswerecollectedandRNAisolated48hoursafterfirstinjection.SampleswereanalyzedbyqRT-PCRforLaminA/Cgeneexpressionlevels.RibosomalRNAlevelswereusedtonormalizetheLaminA/Cdata.Dataaremeans±SD(n=6).
Figure4.Intratumoraladministration(i.t.)ofPolymer-basedInVivoreagentconjugatedwithsiRNAtargetingLaminA/CmRNAornon-silencingcontrolsiRNAfollowingtherecommendedprotocol.TissueswerecollectedandRNAisolated48hoursafterfirstinjection.SampleswereanalyzedbyqRT-PCRforLaminA/Cgeneexpressionlevels.RibosomalRNAlevelswereusedtonormalizetheLaminA/Cdata.Dataaremeans±SD(n=6).
NANOPARTICLE-basedInVivoTransfectionKitforRodents(Mouse,Rat)
Figure5.Systemicadministration(i.v.)ofNanoparticle-basedInVivoreagentconjugatedwithsiRNAtargetingLaminA/CmRNAornon-silencingcontrolsiRNAfollowingtherecommendedprotocol.TissueswerecollectedandRNAisolated48hoursafterfirstinjection.SampleswereanalyzedbyqRT-PCRforLaminA/Cgeneexpressionlevels.RibosomalRNAlevelswereusedtonormalizetheLaminA/Cdata.Dataaremeans±SD(n=6).
Figure6.Intratumoraladministration(i.t.)ofNanoparticle-basedInVivoreagentconjugatedwithsiRNAtargetingLaminA/CmRNAornon-silencingcontrolsiRNAfollowingtherecommendedprotocol.TissueswerecollectedandRNAisolated48hoursafterfirstinjection.SampleswereanalyzedbyqRT-PCRforLaminA/Cgeneexpressionlevels.RibosomalRNAlevelswereusedtonormalizetheLaminA/Cdata.Dataaremeans±SD(n=6).
PEG-LiposomeInVivoTransfectionKitforRodents(Mouse,Rat)
Figure7.Systemicadministration(i.v.)ofLiposome-PEGbasedInVivoreagentconjugatedwithsiRNAtargetingLaminA/CmRNAornon-silencingcontrolsiRNAfollowingtherecommendedprotocol.TissueswerecollectedandRNAisolated48hoursafterfirstinjection.SampleswereanalyzedbyqRT-PCRforLaminA/Cgeneexpressionlevels.RibosomalRNAlevelswereusedtonormalizetheLaminA/Cdata.Dataaremeans±SD(n=6).
Figure8.Intratumoraladministration(i.t.)ofLiposome-PEGbasedInVivoreagentconjugatedwithsiRNAtargetingLaminA/CmRNAornon-silencingcontrolsiRNAfollowingtherecommendedprotocol.TissueswerecollectedandRNAisolated48hoursafterfirstinjection.SampleswereanalyzedbyqRT-PCRforLaminA/Cgeneexpressionlevels.RibosomalRNAlevelswereusedtonormalizetheLaminA/Cdata.Dataaremeans±SD(n=6).
Tissue-targeted InVivoTransfectionReagentsforRodents(Mouse,Rat):
AllAltogen®InVivo TransfectionKitssuppliedwithready-to-runtransfectionprotocolsthateliminatetheneedforextensivetransfectionoptimizationexperiments.Readmore abouttransfectiontechnologyatAltogen’sTransfectionResource.
Selected invivo transfectionproductcitations(ALTOGEN® INVIVO TransfectionKits usedinthefollowingpublications):
AltogenBiosystems:
AltogenBiosystemsprovidespreoptimizedtransfectionproductsforlifescienceresearchapplications.Transfectionprotocolsareoptimizedforindividualcancercelllines.AltogenBiosystemsdevelopedtwotypesofinvivodeliverykitsforanimalresearch:Tissue-targetedreagents(deliverytoliver,pancreas,andkidneytissues),andbroadrangeinvivodeliveryreagents(PEG-Liposome,Nanoparticle-based,Lipid-based,andPolymer-basedkits).Advancedformulationofreagentsandoptimizedtransfectionprotocolsprovideefficientintracellulardeliveryofproteins,DNA,RNA,andanyothernegativelychargedmoleculesinvitroandinvivo.Readmore abouttransfectiontechnologyatAltogen’sTransfectionResource.
AltogenLabsResearchServices:
AltogenLabsprovidesGLP-compliantcontractresearchstudiesforpre-clinicalresearch,INDapplications,anddrugdevelopment.BiologyCROservices include:Xenograftmodels(30+),developmentofstablecelllines,ELISAassaydevelopment,cell-basedandtissuetargetedRNAistudies,safetypharm/toxassays,andotherstudies(visitAltogenLabs.com).
Altogen Biosystems是一家开发和制造用于生命科学研究,药物发现和开发的转染试剂盒的生物技术公司。转染试剂盒针对特定癌细胞系和原代细胞培养进行了优化,可将生物分子有效递送到靶组织中。通过先进的试剂配方和优化的转染方案实现体外(癌细胞系)和体内(动物组织靶向试剂、癌细胞系)递送货物分子,包括质粒DNA,各种类型的RNA(mRNA,siRNA,shRNA,microRNA),蛋白质和小分子研究。
苏州蚂蚁淘代理Altogen Biosystems在中国的业务。Altogen Biosystems北京代理,Altogen Biosystems华东代理,Altogen Biosystems华北代理,Altogen Biosystems全国代理,Altogen Biosystems华南代理。